Dr. Richard Isaacson joined Laugh Lines with Kim & Penn Holderness to answer listener questions about Alzheimer’s prevention, genetic risk, and the latest advances in brain health. Building on Penn Holderness’s recent revelation that he carries two copies of the APOE4 gene, the conversation focused on practical, science-backed strategies for reducing risk and why a family history or genetic predisposition does not determine a person’s future.

Throughout the episode, Dr. Isaacson discusses what to ask your doctor, the prevention plan he developed for Penn, promising lifestyle interventions, and the future of affordable at-home Alzheimer’s risk testing. Most importantly, he shares a hopeful message: while genes play a role, there are meaningful steps people can take today to protect their brain health.

Listen to the full episode to hear Dr. Isaacson’s expert insights on Alzheimer’s prevention, personalized brain health, and why knowledge is power when it comes to reducing risk.