Dr. Richard Isaacson was featured by CNN discussing new research showing that chronic pain—particularly pain affecting multiple areas of the body—may be associated with a higher risk of cognitive decline and dementia. The study found that as the number of chronic pain sites increased, participants experienced greater hippocampal atrophy, faster cognitive decline, and a higher likelihood of developing dementia. Dr. Isaacson emphasized that the findings identify an association rather than proving that chronic pain causes dementia.

Commenting on the research, Dr. Isaacson noted that identifying and treating chronic pain may represent a modifiable risk factor for cognitive decline. He also highlighted the importance of regular physical activity, explaining that exercise is one of the most effective evidence-based strategies for supporting brain health and reducing dementia risk, while acknowledging that chronic pain can make it more difficult for many people to stay active. He further pointed to the growing evidence linking chronic pain, inflammation, and brain health, reinforcing the need for comprehensive, personalized approaches to Alzheimer’s prevention.

Read the full CNN article to learn more about the emerging connection between chronic pain, cognitive decline, and Alzheimer’s disease risk.